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Pycnogenol also has an effect on blood flow (improving microcirculation), which might aid brain oxygenation and nutrient delivery

Additionally, in CD4 + T cells from the peripheral blood of patients with rheumatoid arthritis, catalpol upregulates miR-143-3p, inhibits the abnormal differentiation of Th17 cells, and downregulates glycolysis, thereby regulating the immune balance and exerting anti-inflammatory effects (Shen et al., 2022